CASE REPORT: SPECIFIC ABL-INHIBITOR IMATINIB IS AN EFFECTIVE TARGETED AGENT AS THE FIRST LINE THERAPY TO TREAT B-CELL ACUTE LYMPHOBLASTIC LEUKEMIA WITH A CRYPTIC NUP214::ABL1 GENE FUSION

Acute lymphoblastic leukemia (ALL) with recurrent genetic lesions, affecting a series of kinase genes, is associated with unfavorable prognosis, however, it could benefit from treatment with tyrosine kinase inhibitors (TKI).NUP214::ABL1 fusion is detected in 6% of T-cell acute lymphoblastic leukemia (T-ALL), and is very rare in B-ALL.We present a c

Predatory and scavenging birds may be exposed to high levels of lead when they ingest shot or bullet fragments embedded in the tissues of animals injured or killed with lead ammunition.Lead poisoning was a contributing factor in the decline of the endangered California condor population in the 1980s, and remains one of the primary factors threateni

In the early termination of public-private partnership (PPP) projects, compensation is considered a core issue that greatly affects the interests of the government and the private sector.To address the early termination that is frequently caused by government default or voluntary buyback, this paper proposes an ex-ante compensation mechanism using

Introduction: Legg-Calve-Perthes disease is a juvenile idiopathic aseptic, non-inflammatory, osteonecrosis of immature hip in which the blood supply of femoral epiphysis is not sufficient and the bone dies provisionally followed by a subchondral fracture, fragmentation, revascularization and remodeling.It is associated with both substantial hip pai